er degrader 1 — TargetMol Chemicals

Search Result

Search Results for " er degrader 1 "

Compounds

Cat No.	Product Name	Targets
T63675	ER degrader 1
	ER degrader 1 is a potent degrader of the estrogen receptor (ER). The estrogen signaling system plays an important role in the regulation of cell growth, differentiation and apoptosis, and ER degrader 1 has shown potenti...
T74857	ER degrader 5
	ER Degrader 5 is a potent compound that degrades the estrogen receptor (ER), exhibits anti-proliferation activity, and has potential applications in breast cancer research [1].
T74221	ER degrader 2
	ER Degrader 2, a potent estrogen receptor (ER) degrader, plays a significant role in the estrogen signaling system, which is crucial for regulating cell growth, differentiation, and apoptosis. It holds promise for resear...
T74222	ER degrader 3
	ER degrader 3, a potent estrogen receptor (ER) degrader, significantly impacts the estrogen signaling pathway, which is crucial for regulating cell growth, differentiation, and apoptosis. This compound holds potential fo...
T77985	AZD9496 deacrylic acid phenol	Ligands for Target Protein for PROTAC
	AZD9496 deacrylic acid phenol (AZD9496) represents a portion of the ligand that targets the protein for PROTAC ER Degrader-4 [1].	Ligands for Target Protein for PROTAC
T74856	ER degrader 4
	ER degrader 4, a selective and orally active compound, effectively degrades estrogen receptors and exhibits anti-tumor activity [1].
T79382	ER degrader 6	Estrogen Receptor/ERR
	ER degrader 6 (compound 35s) is a potent selective estrogen receptor modulator (SERM) with the capacity to degrade Estrogen Receptor (ER)α. It disrupts the microtubule network, inhibiting tubulin polymerization, and effe...	Estrogen Receptor/ERR
T18607	PROTAC ER Degrader-3	Others
	PROTAC ER Degrader-3, an intermediate for the synthesis of PAC, specifically compound LP2. PAC serves as the linker for ADCs and PROTACs that are conjugated to an antibody. Notably, when PAC is conjugated to an antibody,...	Others
T18606	PROTAC ER Degrader-2	Others
	PROTAC ER Degrader-2 serves as a synthesis intermediate for the production of PAC, a compound that incorporates the ADCs linker and PROTACs, which are subsequently conjugated to an antibody. PAC, exhibits a greater capab...	Others
T79383	ER degrader 7
	ER degrader 7 (Compound 35t) is a selective degrader of both ERα and ERβ, and possesses activity as a tubulin polymerization inhibitor. It exhibits potent cell viability inhibition, with IC50 values of 0.06 μM for MCF-7,...
T74593	Taragarestrant meglumine
	Taragarestrant (D-0502) meglumine is a potent, orally active, and selective estrogen receptor degrader (SERD) demonstrating significant efficacy in ER+ breast cancer cell lines and xenograft models [1] [2].
T78824	ERD-3111	Estrogen Receptor/ERR
	ERD-3111 (Compound 44), an orally active PROTAC ERα degrader (DC50: 0.5 nM), exhibits efficacy in inhibiting tumor growth in both the parental MCF-7 xenograft model harboring wild-type ER and two ESR1-mutated mouse model...	Estrogen Receptor/ERR
T74415	Imlunestrant tosylate
	Imlunestrant tosylate (LY-3484356) is a potent, orally active selective estrogen receptor degrader (SERD) exhibiting purely antagonistic properties. It effectively maintains inhibition of estrogen receptor (ER)-dependent...
T82439	Estrogen receptor modulator 10	Estrogen Receptor/ERR
	Compound G-5b, an estrogen receptor modulator 10, functions as an estrogen receptor (ER) antagonist (IC50=6.7 nM) and degrader (DC50=0.4 nM). It has the capability to induce apoptosis and block cells at the G1/G0 phase, ...	Estrogen Receptor/ERR